Covering the most devastating disease in the Western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque.Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner.A must-have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.
Spis treści:
* INTRODUCTION
* PATHOGENESIS OF ATHEROSCLEROSIS. Sarah George & Cressida Lyon
* PROINFLAMMATORY FACTORS
* CHEMOKINES AND ATHEROSCLEROSIS: A CRITICAL ASSESSMENT OF THERAPEUTIC TARGETS. Gemma White, Keith Channon & David Greaves
* ADHESION MOLECULES AND ATHEROSCLEROSIS Huan Wang & Yuqing Huo
* CYTOKINES AND ATHEROSCLEROSIS. Alain Tedgui, Hafid Ait-Oufella and Ziad Mallat
* TOLL-LIKE RECEPTORS IN ATHEROSCLEROSIS Zhong-qun Yan, Kristina Edfeldt & Anna Lundberg
* PPAR-BASED THERAPIES FOR THE MANAGEMENT OF ATHEROSCLEROSIS Florence Gizard & Ines Pineda-Torra
* PENTRAXINS IN VASCULAR PATHOLOGY: THE ROLE OF PTX3. Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Fabiola Molla & Roberto Latini
* PROTEASES
* METALLOPROTEINASES, THE ENDOTHELIUM AND ATHEROSCLEROSIS Stephen White & Andrew Newby
* CATHEPSINS IN ATHEROSCLEROSIS Lili Bai, Esther Lutgens & Sylvia Heeneman
* THE PLASMIN SYSTEM AND ATHEROSCLEROSIS Chris Jackson & Kevin Carson
* MAST CELL PROTEASES AND ATHEROSCLEROSIS Petri Kovanen
* HYPERLIPIDEMIA
* MACROPHAGE FOAM CELL FORMATION: THE PATHWAYS TO CHOLESTEROL ENGORGEMENT. Kathryn Moore & Katey Rayner
* OXIDATIVE STRESS
* NADPH OXIDASE AND ATHEROSCLEROSIS Jamie Jeremy, Saima Muzaffar, Carina Mill & Nilima Shukla
* UNCOUPLING OF ENDOTHELIAL NITRIC OXIDE SYNTHASE IN ATHEROSCLEROSIS. Colin Cunnington & Keith Channon
* HEME OXYGENASE-1 AND ATHEROSCLEROSIS Justin Mason & Faisal Ali
* CELL GROWTH AND PHENOTYPE
* PHENOTYPIC HETEROGENEITY OF SMOOTH MUSCLE CELLS. IMPLICATIONS FOR ATHEROSCLEROSIS Marie-Matteo Coen and Luce Bochaton-Piallat
* PLATELETS: THEIR ROLE IN ATHEROGENESIS AND THROMBOSIS IN CORONARY ARTERY DISEASE. Matthew Harper, Lucy MacCarthy-Morrogh, Matthew Jones, Olga Konopatskaya & Alastair Poole
* MODULATORS OF MONOCYTE AND MACROPHAGE PHENOTYPES IN ATHEROSCLEROSIS Nick Jenkins & Jason Johnson
